RNA methyltransferase NSun2 deficiency promotes neurodegeneration through epitranscriptomic regulation of tau phosphorylation.

"This work was supported by NIH Grants R01NS095922 and P50AG0008702 to I.S.M., R01MH117790 to S.A., R03NS112785, R25NS070697, R21AG070414-01 and K08NS116166-01 to G.H., and R01AG050658 to F.B. and NIMH Postdoctoral fellowship F32MH115565-01A1 to J.B. Additional support was provided to I.S.M. by the Alzheimer’s Association (NIRG-15-3644-58). G.H. and A.A.S. were supported by the Henry and Marilyn Taub Foundation and the Thompson Family Foundation Program (TAME-AD). We want to thank Dr. Jean Paul Vonsattel for neuropathology support. We are grateful to the late Dr. Peter Davies for his generous gift providing us PHF1 anti-phospho-tau antibody. Finally, we want to thank Dr. Stephan J. Sigrist who kindly shared with us the transgenic Drosophila line."