Fast-forwarding evolution-Accelerated adaptation in a proofreading-deficient hypermutator herpesvirus.

"raw sequencing data and alignments are available at the national center for biotechnology information (ncbi) short read archive bioproject prjna854607.; data availability raw sequencing data and alignments are available at the ncbi short read archive bioproject prjna854607. custom code used for data analysis is available at github ( https://github com/mmnascimento/fastforwardingevolution ). data availability raw sequencing data and alignments are available at the ncbi short read archive bioproject prjna854607"

"all snp-containing orfs sequences were extracted from these consensus genomes and translated using a custom-made script (available at https://github com/mmnascimento/fastforwardingevolution ).; a version of the notebook complete with recorded variables and outputs from the analysis performed here (mdv_protein_analysis ipynb) is also available on github.; custom code used for data analysis is available at github ( https://github com/mmnascimento/fastforwardingevolution )."

"Conflict of interest: None declared."

"We are grateful to Ann Reum, Annett Neubert, and Laurie Molitor for excellent technical assistance. We thank Dr. Michael Veit for providing T7 chicken intestinal epithelial cells. T.H., N.O., and D.P.M. were supported by the Volkswagenstiftung (Grant No. 96692)."