The fatty acid imbalance of cystic fibrosis exists at birth independent of feeding in pig and ferret models.

"data availability all data presented herein are available publicly at https://doi"

"Competing Interests The authors declare that there are no competing interests associated with the manuscript."

"Funding This work was supported by National Institute of Health (NIH) [grant numbers DK124207 (to J.F.E. and A.W.N.), DK084049 (to A.U.), DK108334 (to A.U.), DK097820 (to A.U. and A.W.N.), and DK115791 (to A.W.N. and J.F.E.)]; the Swedish Research Council (to B.S.); the Erica Lederhausen Foundation (to B.S.); the Royal Society of Arts and Science in Gothenburg (to B.S.); FOEDRC scholar award (to A.W.N.); the National Institute of Health (NIH) [grant numbers HL091842 and DK054759]; the Iowa Cystic Fibrosis Foundation Research Development Program [grant number R458-CR07]; Instrument acquisition and lipidomics method development at the Kansas Lipidomics Research Center were supported by the National Science Foundation (including support from the Major Research Instrumentation program; current award DBI-1726527), K-IDeA Networks of Biomedical Research Excellence (INBRE) of NIH [grant number P20GM103418]; and USDA National Institute of Food and Agriculture (Hatch/Multi-State project 1013013)."