Proteogenomic insights into the biology and treatment of pancreatic ductal adenocarcinoma.

"all the wes raw data have been deposited at node ( https://www biosino org/node/ ) with accession number (oep001784).; all the rna-seq raw data have been deposited at gsa ( https://ngdc cncb ac cn/gsa/ ) with the accession number (hra002195)."

"Declarations Ethics approval and consent to participateThe present study about human was carried out comply with the ethical standards of Helsinki Declaration II and approved by the Institution Review Board of Fudan University Zhongshan Hospital (B2019-200R).The animal study was carried out comply with American Veterinary Medical Association (AVMA) Guidelines for the Euthanasia of Animals (2020) and approved by Department of experimental animal science, Fudan University (201802143s). Consent for publicationAll authors give consent for the publication of the manuscript in Journal of Hematology & Oncology. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work is supported by National Key R&D Program of China: 2022YFA1303200, 2022YFA1303201; National Key R&D Program of China: 2017YFA0505102, 2016YFA0502500, 2018YFA0507501, 2017YFC0908404, 2020YFE0201600, 2018YFE0201603, 2017YFA0505101; National Natural Science Foundation of China: 31770886, 31972933, 31700682, 32201212; Shanghai Municipal Science and Technology Major Project: 2017SHZDZX01; Shuguang Program of Shanghai Education Development Foundation and Shanghai Municipal Education Commission: 19SG02; Program of Shanghai Academic/Technology Research Leader; Major Project of Special Development Funds of Zhangjiang National Independent innovation Demonstration Zone: ZJ2019-ZD-004; China Postdoctoral Science Foundation: 2019M651268; National Postdoctoral Program for Innovative Talents; The Fudan original research personalized support project; and CAMS Innovation Fund for Medical Sciences (CIFMS): 2019-12M-5-063."