Ameliorating Role of Hydrogen-Rich Water Against NSAID-Induced Enteropathy via Reduction of ROS and Production of Short-Chain Fatty Acids.

"Declarations Conflict of interestThe authors declare that they have no conflicts of interest. Ethical approvalEight-week-old male C57BL/6J mice were purchased from CLEA Japan (Tokyo, Japan). They were cared for as per the guidelines of the animal facility at the National Defense Medical College (NDMC). This study was approved by the Animal Research Committee of the NDMC (No. 20011). Conflict of interest The authors declare that they have no conflicts of interest."

"This research was supported by grants from the National Defense Medical College and from the Japan Foundation for Applied Enzymology and by a Health and Labor Sciences research grant into research on intractable diseases, from the Ministry of Health, Labor and Welfare, Japan. We would like to thank Mr. Takanori Konuma (TAKAOKA TOKO CO., LTD.), Mr. Shunichi Suzuki (TAKAOKA TOKO CO., LTD.), and Mr. Takeshi Kawashima (TAKAOKA CHEMICAL CO., LTD.) for their help on preparation of hydrogen-rich water, Ms. Hanae Tsuchihashi (Meiji Co., Ltd.) for the technical support to analyze the microbiota, and Editage (www.editage.com) for English language editing."