Efficient generation of epigenetic disease model mice by epigenome editing using the piggyBac transposon system.

"Declarations Ethics approval and consent to participateAll animal procedures were approved by the Animal Care and Experimentation Committee at Gunma University (No. 21-040) and carried out in accordance with approved guidelines. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no conflicts of interest related to the contents of this article. Competing interests The authors declare that they have no conflicts of interest related to the contents of this article."

"Funding This work was supported by funding from the Basic Science and Platform Technology Program for Innovative Biological Medicine from the Ministry of Education, Culture, Sports, Science and Technology, Japan (MEXT) to T.H., S.M., and I.H.; the Japan Agency for Medical Research and Development (AMED) under Grant Number 21gm6310009h0003 to S.M.; the Research Support Project for Life Science and Drug Discovery (Basis for Supporting Innovative Drug Discovery and Life Science Research (BINDS)) from AMED under Grant Number JP22ama121049 to I.H.; the Tokyo Biochemical Research Foundation to I.H.; the Takeda Science Foundation to I.H.; and the Practical Research Project for Rare/Intractable Diseases from AMED to I.H."