Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes.

"single-cell rna-seq data have been deposited at geo (gse175546) and are publicly available as of the date of publication."

"Declarations Ethics approval and consent to participateAll animal procedures were in accordance strictly with the National Institutes of Health Guide for the Care and Use of Laboratory Animals and were approved by the Johns Hopkins University Animal Care and Use Committee. Consent for publicationAuthors consent for the publication. All authors read and approved the final manuscript. Competing interestsS.B. receives research support from Genentech, is a co-founder and scientific advisory board member of CDI Labs LLC, and is/was a consultant for Third Rock Ventures and Tenpoint Therapeutics. Competing interests S.B. receives research support from Genentech, is a co-founder and scientific advisory board member of CDI Labs LLC, and is/was a consultant for Third Rock Ventures and Tenpoint Therapeutics."

"Funding This work was supported in part by the Maryland Stem Cell Research Fund (2019-MSCRFF-5124) to DWK, grants from the National Institute of Aging (R56AG068089) to RLS and TL, (R21AG073710) to TL, and the National Institute of Neurological Disorders and Stroke (R61NS115161 and R01NS095969) to PCW."