Insights into the pathogenesis of hereditary angioedema using genetic sequencing and recombinant protein expression analyses.

"Disclosure of potential conflict of interest: H. J. Wedner reports receiving research funding from BioMarin, KalVista, Pharvaris, and Takeda; consulting fees from CSL, Takeda, BioCryst, and BioMarin; and speaking fees from Genentech, GlaxoSmithKline, CSL, Takeda, and BioCryst. The rest of the authors declare that they have no relevant conflicts of interest. This study has been supported by the Division of Allergy and Immunology in the Department of Medicine at the Washington University School of Medicine, the National Institutes of Health under award R35 GM136352 (J.P.A.), and the Washington University Institute of Clinical and Translational Sciences, which is, in part, supported by the National Institutes of Health/National Center for Advancing Translational Sciences (CTSA grant no. UL1TR002345). This publication is solely the responsibility of the authors and does not necessarily represent the official view of the National Center for Research Resources or the National Institutes of Health. We thank Dr Jonathan Sheehan and M. Kathryn (Kathy) Liszewski (WUSM) for their helpful suggestions related to structural analysis, experimental design, and manuscript preparation. We also thank the participants of the HAE study without whose collaboration this study could not have been accomplished. We thank the clinical research team in the Division of Allergy and Immunology at WUSM who were responsible for patient recruitment, samples, and data handling. We thank the Genome Technology Access Center in the Department of Genetics at Washington University School of Medicine for help with genomic analysis. This center is partially supported by NCI Cancer Center Support Grant P30CA91842 to the Siteman Cancer Center and by ICTS/CTSA (grant no. UL1TR002345) from the National Center for Research Resources, a component of the National Institutes of Health (NIH), and the NIH Roadmap for Medical Research."

"This study has been supported by the Division of Allergy and Immunology in the Department of Medicine at the Washington University School of Medicine, the National Institutes of Health under award R35 GM136352 (J.P.A.), and the Washington University Institute of Clinical and Translational Sciences, which is, in part, supported by the National Institutes of Health/National Center for Advancing Translational Sciences (CTSA grant no. UL1TR002345). This publication is solely the responsibility of the authors and does not necessarily represent the official view of the National Center for Research Resources or the National Institutes of Health. We thank Dr Jonathan Sheehan and M. Kathryn (Kathy) Liszewski (WUSM) for their helpful suggestions related to structural analysis, experimental design, and manuscript preparation. We also thank the participants of the HAE study without whose collaboration this study could not have been accomplished. We thank the clinical research team in the Division of Allergy and Immunology at WUSM who were responsible for patient recruitment, samples, and data handling. We thank the Genome Technology Access Center in the Department of Genetics at Washington University School of Medicine for help with genomic analysis. This center is partially supported by NCI Cancer Center Support Grant P30CA91842 to the Siteman Cancer Center and by ICTS/CTSA (grant no. UL1TR002345) from the National Center for Research Resources, a component of the National Institutes of Health (NIH), and the NIH Roadmap for Medical Research."