Identification of potential anti-pneumonia pharmacological components of <i>Glycyrrhizae Radix</i> et Rhizoma after the treatment with Gan An He Ji oral liquid.

"the sample collection process is detailed in section 1 "collection of clinical samples" in the supplementary data 2 3 male sd rats weighing 200-220 g and c57bl/6 mice weighing 18-20 g were used in the animal experiments.; the animal adaptive feeding process is detailed in section 2 "animal experiments" in the supplementary data 2 3 1 gahj was administered to the rats ( n = 6) intragastrically at 20 ml/kg.; the drug administration and sample collection process are detailed in section 2 1 "collection of plasma urine and feces samples" and section 2 2 "collection of bile samples" in the supplementary data 2 3 2 2 3 2 1 the mice were randomly divided into four groups: control (con) model (lps) pharmacodynamic component treatment (lps-mix) and gahj treatment (lps-gahj) groups (with 10 mice in each group).; the sample preparation processes are detailed in section 3 "sample preparation" in the supplementary data 2 4 3 the rat fecal samples collected at 0-24 h after the administration of gahj were mixed.; the sample preparation process is detailed in section 3 6 "pretreatment of rat fecal samples" in the supplementary data 2 5 the sample detection was performed with a thermo fisher q exactive orbitrap mass spectrometer (thermo fisher scientific inc waltham ma usa).; the detailed procedures are described in section 4 "immunohistochemistry assay" in the supplementary data 2 9 mouse inos and tnf-?"

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"This research was funded by the 10.13039/501100001809National Natural Science Foundation of China (Grant Nos.: 82141215, 82173694, 82173779, 82222068, and U1903119), Fujian Province Science and Technology Project (Grant Nos.: 2021J011340 and 2020Y0013), and Xiamen Municipal Bureau of Science and Technology Planning Project (Grant No.: 3502Z2021YJ11). Xiaojuan Jiang: Writing - Original draft preparation, Reviewing and Editing, Conceptualization, Methodology; Yihua Lin: Funding acquisition, Resources, Writing - Reviewing and Editing; Yunlong Wu: Writing - Original draft preparation, Reviewing and Editing; Caixia Yuan, Xuli Lang, and Jiayun Chen: Data curation, Writing - Reviewing and Editing; Chunyan Zhu: Validation; Xinyi Yang and Yu Huang: Formal analysis; Hao Wang and Caisheng Wu: Writing - Original draft preparation, Conceptualization, Methodology, Funding acquisition."