Urinary profiles of methoxyphenamine and its metabolite after inhalation of methoxyphenamine smoke in humans: aiming to distinguish between active and passive exposure.

"file 1 (docx 84 kb) supplementary file 2 (xlsx"

"Declarations Conflict of interestThe authors declare that they have no conflict of interest. Ethical approvalAll animal experiments were conducted in accordance with the guidelines set by the Science Council of Japan, and the experimental protocol was approved by the Institutional Animal Care and Use Committees of Showa University (Approval No. 23024). Every effort was made to minimize the number of animals used and their suffering. All procedures for the study involving human subjects were conducted in accordance with the Declaration of Helsinki and the Clinical Trials Act, Japan. The study was approved by the Showa University Clinical Research Review Board (Approval No. CRB3200002) and registered with The Japan Registry of Clinical Trials (jRCT) (Trial ID jRCTs031210604, February 9, 2022). All subjects were given a written explanation and written informed consent was obtained before study registration. Conflict of interest The authors declare that they have no conflict of interest."

"This work was supported by JSPS KAKENHI Grant No. 19K 10693."

"Trial registration number : jRCTs031210604, registration date: Feb. 9, 2022."