Who's afraid of the X? Incorporating the X and Y chromosomes into the analysis of DNA methylation array data.

"table 5 statistical comparisons that can be made with x and y chromosome dname array data study design method case vs control sex-stratified (e g x chromosome dname in xx female case versus unaffected xx female controls) x-chromosome inactivation use average cpg island promoter dname to evaluate whether x linked genes escape or are subject to xci as demonstrated in [ ] for practical application of our recommended modifications to dname processing pipelines we have developed a straightforward r workflow which enables the appropriate integration of x and y chromosome data in processing mixed-sex dname cohorts; see fig 3 and available code at https://github com/amy-inkster/xy_processing_analysis (additional file 4 ).; availability of data and materials code used for processing and analysis of x and y chromosome dname data is available at https://github com/amy-inkster/xy_processing_analysis . table s2. provided as separate xlsx"

"table 5 statistical comparisons that can be made with x and y chromosome dname array data study design method case vs control sex-stratified (e g x chromosome dname in xx female case versus unaffected xx female controls) x-chromosome inactivation use average cpg island promoter dname to evaluate whether x linked genes escape or are subject to xci as demonstrated in [ ] for practical application of our recommended modifications to dname processing pipelines we have developed a straightforward r workflow which enables the appropriate integration of x and y chromosome data in processing mixed-sex dname cohorts; see fig 3 and available code at https://github com/amy-inkster/xy_processing_analysis (additional file 4 ).; availability of data and materials code used for processing and analysis of x and y chromosome dname data is available at https://github com/amy-inkster/xy_processing_analysis ."

"Declarations Ethics approval and consent to participateEthics approval for use of human research subjects in this study was obtained from the University of British Columbia and the Children’s and Women’s Health Centre of British Columbia Research Ethics Board (H18-01695). Informed written consent was obtained from all study participants. Consent for publicationNot applicable. Competing interestsThe authors declare no competing interests. Competing interests The authors declare no competing interests."

"Funding This work was supported by a Canadian Institutes of Health Research (CIHR) Grant to WPR [SVB-158613 and F19-04091]. WPR holds a CIHR Research Chair in Sex and Gender Science [GSK-171375] and receives salary support through an investigatorship award from the BC Children’s Hospital Research Institute; AMI receives support from a CIHR Doctoral Fellowship."