Cryo-EM structures of amyloid-β filaments with the Arctic mutation (E22G) from human and mouse brains.

"corresponding refined atomic models have been deposited in the protein data bank (pdb) under accession numbers8bfz 8bg0 and 8bg9."

"Declarations Conflict of interestThe authors declare that they have no conflicts of interest. Ethical approvalStudies carried out at Indiana University and the Karolinska Institutet (2011/962-31/1) were approved through the ethical review processes at each Institution’s Review Board. Informed consentInformed consent was obtained from the patient’s next of kin. This study was approved by the Cambridgeshire 2 Research Ethics Committee (09/H0308/163). Conflict of interest The authors declare that they have no conflicts of interest."

"Funding This work was supported by the UK Medical Research Council, as part of UK Research and Innovation (MC_UP_A025-1013 to S.H.W.S. and MC_U105184291 to M.G.) and by the US National Institutes of Health (UO1-NS110457)."