A Phase II randomized controlled trial of oral prednisolone in early diffuse cutaneous systemic sclerosis (PRedSS).

"treatment adherence and a description of how this was calculated is given in supplementary data s1 available at rheumatology online."

"Disclosure statement : J.D.P. has received speaker fees from Janssen and consultancy fees from Janssen, Astra Zeneca, Permeatus Inc., Boehringher-Ingelheim and Sojournix Pharma. F.H. has received research grants from BMS, Alexion and Lilly; consultancy with Roche. P.L. has received consultancy fees from Pfizer and research funding from Vifor Pharma. H.G. has received speaker fees from Boehringer Ingelheim. M.A. has received consultancy fees from Gilead, Nordic pharma, speaker fees from Janssen and sponsorship to attend meetings from GSK, Eli Lilly, Roche and AstraZeneca. B.G. is the Chair of NHS England’s Clinical Reference Group for Specialized Rheumatology. C.P.D. reports grants and personal fees from Acceleron, Janssen, Arxx Therapeutics, Bayer, Boehringer Ingelheim, Corbus, CSL Behring, Galapagos, GlaxoSmithKline, Horizon, Roche, and Abbvie; all outside the submitted work. A.L.H. has received consultancy fees from Arena, Boehringer-Ingelheim, Camurus, CSL Behring and Gesynta Pharma, speaker fees from Actelion and Janssen, and research funding from Actelion and Gesynta Pharma."

"Funding This work was supported by Versus Arthritis (grant number 21021). Disclosure statement: J.D.P. has received speaker fees from Janssen and consultancy fees from Janssen, Astra Zeneca, Permeatus Inc., Boehringher-Ingelheim and Sojournix Pharma. F.H. has received research grants from BMS, Alexion and Lilly; consultancy with Roche. P.L. has received consultancy fees from Pfizer and research funding from Vifor Pharma. H.G. has received speaker fees from Boehringer Ingelheim. M.A. has received consultancy fees from Gilead, Nordic pharma, speaker fees from Janssen and sponsorship to attend meetings from GSK, Eli Lilly, Roche and AstraZeneca. B.G. is the Chair of NHS England’s Clinical Reference Group for Specialized Rheumatology. C.P.D. reports grants and personal fees from Acceleron, Janssen, Arxx Therapeutics, Bayer, Boehringer Ingelheim, Corbus, CSL Behring, Galapagos, GlaxoSmithKline, Horizon, Roche, and Abbvie; all outside the submitted work. A.L.H. has received consultancy fees from Arena, Boehringer-Ingelheim, Camurus, CSL Behring and Gesynta Pharma, speaker fees from Actelion and Janssen, and research funding from Actelion and Gesynta Pharma."

"Trial registration ClinicalTrials.gov, https://clinicaltrials.gov, NCT03708718."