STAT3 regulates CD8+ T cell differentiation and functions in cancer and acute infection.

"figure s1 stat3 is intrinsically critical for the effector function of cd8 + t cells (a) mrna level of stat3 in cd8 + t cells from peripheral blood or tumors in human cancer patients (geo accession nos gse99254 gse108989 and gse98638 ) scrna-seq data of cd8 + t cells in tumors and peripheral blood from lung crc and hcc patients were previously processed and uploaded by others ( http://crc cancer-pku cn/ http://hcc cancer-pku cn/ http://lung cancer-pku cn/ ; ; ; ) and we obtained the stat3 expression values from the above websites.; stat3 -/- ot-i cells transferred into b16-ova-bearing mice ( fig 2 ) are available in the geo database under accession no gse217375 .; stat3 -/- ot-i cells transferred into b16-ova-bearing mice ( fig 6 ) are available in the geo database under accession no gse217372 .; stat3 -/- cd8 + t cells ( fig 6 ) are available in the geo database under accession no gse217374 . data availability data from rna-seq of wt vs. stat3 -/- ot-i cells transferred into b16-ova-bearing mice ( fig 2 ) are available in the geo database under accession no gse217375"

"Disclosures: The authors declare no competing interests exist."

"This work was supported by grants from the Natural Science Foundation of China (31991173, 31821003, and 31991170), the National Key Research and Development Program of China (2021YFC2302403), Tsinghua University Spring Breeze Fund (2020Z99CFG008), Innovative Research Team of High-level Local Universities in Shanghai, Tsinghua University-Xiamen Chang Gung Hospital Joint Research Center for Anaphylactic Disease, and Shanghai Jiao Tong University-Bennu Biotherapeutics Joint Laboratory for Cell Therapy."