Overexpression of alpha synuclein disrupts APP and Endolysosomal axonal trafficking in a mouse model of synucleinopathy.

"We would like to thank the Wu and Rissman laboratories for their assistance in providing technical support. This work was supported by NIH/NIA R01 grants AG018440 and AG073979 to RAR., and UCSD ADRC AG062429 Pilot funding and NS092525 to CW. CRediT authorship contribution statement: Suzhen Lin: Conceptualization, Methodology, Investigation, Formal analysis. André D.G. Leitão: Formal analysis, Data curation, Software, Writing – original draft, Writing – review & editing, Visualization. Savannah Fang: Investigation. Yingli Gu: Investigation. Sophia Barber: Investigation. Rhiannon Gilliard-Telefoni: Investigation. Alfredo Castro: Investigation. Kijung Sung: Investigation. Ruinan Shen: Investigation. Jazmin B. Florio: Investigation. Michael L. Mante: Investigation. Jianqing Ding: Investigation. Brian Spencer: Writing – review & editing. Eliezer Masliah: Supervision, Writing – review & editing, Project administration, Funding acquisition. Robert A. Rissman: Supervision, Writing – review & editing, Project administration, Funding acquisition. Chengbiao Wu: Supervision, Writing – review & editing, Project administration, Funding acquisition."