The optimal timing and intervention to reduce mortality for necrotizing pancreatitis: a systematic review and network meta-analysis.

"Declarations Ethics approval and consent to participateNot applicable. Approval by the institutional review board was not needed for the study and was therefore not attained. Written consent was not needed by any parties. Consent for publicationNot applicable. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This research was supported by the Tianjin Science and Technology Project of Traditional Chinese Medicine (no. 2022005), the Key Program of the Natural Science Foundation of Tianjin (21JCZDJC00550), the Scientific Research Fund of Tianjin Municipal Administration of Traditional Chinese Medicine (20211006), and the Tianjin 131 Talents Project (201938)."

"This review followed the Cochrane Handbook of Systematic Reviews and Interventions and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement reporting systematic reviews and network meta-analyses [, ]. This review was registered prospectively in PROSPERO (CRD42022364409). Methods: We searched PubMed, EMBASE, ClinicalTrials.gov and the Cochrane Library until November 30, 2022. A systematic review and Bayesian network meta-analysis were performed following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Trials comparing different treatment strategies for necrotizing pancreatitis were included. This study was registered in the Prospective Register of Systematic Reviews (CRD42022364409) to ensure transparency."