An Interventional Response Phenotyping Study in Chronic Low Back Pain: Protocol for a Mechanistic Randomized Controlled Trial.

"Conflicts of interest: The only conflict of interest is for Dr. Steven Harte who has membership at Arbor Medical Innovations, the manufacturer of sensory testing devices used in this study."

"Funding National Institutes of Health - National Institute of Arthritis and Musculoskeletal and Skin Diseases (U19 AR076734) University of Michigan BACPAC Mechanistic Research Center. Conflicts of interest: The only conflict of interest is for Dr. Steven Harte who has membership at Arbor Medical Innovations, the manufacturer of sensory testing devices used in this study."

"A subset of patients (n = 160) will undergo “deep” phenotyping, with additional testing such as QST, functional magnetic resonance imaging (fMRI), autonomic nervous system (ANS) function assessment, and additional blood collection for basal and stimulated immune markers. There will be two deep phenotyping assessments that take place before and after Treatment 1. This study has been approved by IRBMED at the University of Michigan (HUM# 00180994) and has been registered at ClinicalTrials, gov, NCT 0487057."