Trem2 H157Y increases soluble TREM2 production and reduces amyloid pathology.

"bulk rna sequencing data are available in ncbi's gene expression omnibus with the accession number gse212618."

"Declarations Ethics approval and consent to participateOur mice were housed in a temperature-controlled environment with a 12-h light–dark cycle and free access to food and water. All animal procedures were approved by the Mayo Clinic Institutional Animal Care and Use Committee (IACUC) and in accordance with the National Institutes of Health Guidelines for the Care and Use of Laboratory Animals. Consent for publicationAll authors have given their consent for publication. Competing interestsGB consults for SciNeuro and Vida Ventures, had consulted for AbbVie, E-Scape, and Eisai, and serves as a Co-Editor-in-Chief for Molecular Neurodegeneration. All other authors declare no competing interests. Competing interests GB consults for SciNeuro and Vida Ventures, had consulted for AbbVie, E-Scape, and Eisai, and serves as a Co-Editor-in-Chief for Molecular Neurodegeneration. All other authors declare no competing interests."

"This work was supported by NIH grants R01AG066395 (to G.B. and N.Z.), RF1AG056130, R37AG027924, and RF1AG046205 (to G.B)."