GPR109A controls neutrophil extracellular traps formation and improve early sepsis by regulating ROS/PAD4/Cit-H3 signal axis.

"Declarations Ethics approval and consent to participateThe experiments were approved by the Jilin University Institutional Animal Care and Use Committee. This study was carried out in accordance with the recommendations of the Declaration of Helsinki guidelines and approved by the ethics committee of the China-Japan Union Hospital of Jilin University (20201115). Informed consent was obtained from all patients and volunteers involved in this study. All animal experiments were performed in accordance with the Basel Declaration and approve by Jilin University Institutional Animal Care and Use Committee. Consent for publicationAll authors agree to publish. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding National Key R&D Programmes (2021YFC2701700, 2021YFC2701701)."