NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.

"Disclosure statement No potential conflict of interest was reported by the authors."

"We thank the WCM Proteomics and Metabolomics Core Facility, especially Dr. Guoan Zhang and Dr. Mengmeng Zhu. We thank Dr. Lauren Marek and Dr. Steven Gross for their helpful advice and discussions regarding the proteomic experiments and data analysis, Dr. Francesca Khani and Dr. Ana Molina for their fruitful discussions and clinical insights, everyone in the Gudas and Heller labs for their productive discussions and critical input, Dr. Michal Nagiec for his valuable insight and expertise on lysosomal trafficking, and Yevgeniy Romin and the MSKCC Molecular Cytology Core Facility. This research was supported by the NIH T32 (5 T32 CA062948-22) and F31 (1 F31 CA213814-01) grants provided to Jaclyn Kubala and R01 DK113088-01A1 provided to the Gudas lab. Work in the Heller lab was supported by R01-DK119489, R01-CA215719, and The Cancer Center Support Grant (P30-CA008748). The authors declare that they have no conflicts of interest with the contents of this article."