Cre recombinase expression cooperates with homozygous FLT3 internal tandem duplication knockin mouse model to induce acute myeloid leukemia.

"data availability atac- and rna-sequencing data are available through ncbi gene expression omnibus under accession numbers gse212222.; whole exome- and whole genome-sequencing analysis have been deposited in the ncbi sequencing read archive bioproject id: prjna909339. data availability atac- and rna-sequencing data are available through ncbi gene expression omnibus under accession numbers gse212222"

"Competing interests The authors declare no competing interests."

"The authors thank A. Fenske (Central Animal Facility, OvGU Magdeburg) and M. v.d. Wall (Animal Facility UK Jena) for their support with animal care, M. Locke and K. Schubert (Flow Facility, FLI, Jena) for their support with cell sorting, L. Rothenburger (Core Service Histology, FLI, Jena) for support with histopathology and S. Frey and C. Kathner-Schaffert for technical assistance. This work was supported by grants of the German Cancer Aid (Deutsche Krebshilfe, 70112607), by the Thuringian state program ProExzellenz (RegenerAging–FSU-I-03/14) of the Thuringian Ministry for Research and by a Research Fellowship grant of the European Hematology Association (EHA) to FHH. The work was further supported through NHMRC Project Grant 1098470 and NHMRC investigator grant 1195987 awarded to SWL. TV is a Leukemia and Lymphoma Society and Mark Foundation fellow. We thank Ross Levine, Aaron Viny, Robert Bowman and Scott Armstrong for helpful discussions."