Remodeling of colon plasma cell repertoire within ulcerative colitis patients.

"= 0 4 p value < 2 2 x 10 -16 ; fig 2 d and e ; data s1 ; materials and methods).; data s1 shows the heatmap and phylogenetic trees of expanded clones with igg and iga isotypes.; data s1 shows heatmap and phylogenetic trees of expanded clones with igg and iga isotypes."

"source codes of the scrna-seq and ab repertoire analyses are deposited on github ( https://github com/eraslanbas/ucplasmacellrepertoire )."

"Disclosures: A.N. Ananthakrishnan reported personal fees from Menten AI and Iterative Scopes outside the submitted work. A. Regev reported “other” from Genentech, Roche, Immunitas, and Celsius Therapeutics; and personal fees from ThermoFisher Scientific and Syros outside the submitted work. In addition, A. Regev had various patents related to single cell genomics issued. R.J. Xavier reported non-financial support from Jnana Therapeutics, Celsius Therapeutics, and MoonLake Immunotherapeutics outside the submitted work. No other disclosures were reported."

"This work was supported by the National Institutes of Health (RC2 DK114784 and P30 DK043351 to R.J. Xavier), the Crohn's and Colitis Foundation, and the Klarman Cell Observatory."