Minimal clinically important difference for impulse oscillometry in adults with asthma.

"Conflicts of interest: M. Abdo received travel support from Chiesi and consulting fees from AstraZeneca, all outside the submitted work. E. von Mutius reports personal fees from Pharmaventures, OM Pharma SA, Springer-Verlag GmbH, Elsevier GmbH, Elsevier Ltd, Peptinnovate Ltd, Turun Yliopisto, Tampereen Yliopisto, Helsingin Yliopisto, European Respiratory Society, Deutsche Pharmazeutische Gesellschaft eV, Massachusetts Medical Society, Chinese University of Hongkong, Boehringer Ingelheim, ProtectImmun GmbH, Faculteit Diergeneeskunde, Universität Salzburg, Georg Thieme Verlag, Japanese Society of Pediatric Allergy and Clinical Immunology, and Universiteit Utrecht, all outside the submitted work. K.F. Rabe reports grants from Boehringer Ingelheim and AstraZeneca, as well as personal fees from Boehringer Ingelheim, AstraZeneca, Novartis, Roche, Chiesi Pharmaceuticals, Regeneron, Sanofi and Berlin-Chemie. F. Trinkmann received travel support from Actelion, Berlin-Chemie, Boehringer Ingelheim, Chiesi, Novartis, Mundipharma, TEVA, AstraZeneca, Berlin-Chemie, Bristol-Myers Squibb, Chiesi, GlaxoSmithKline, Novartis, Roche and Sanofi-Aventis, all outside the submitted work. T. Bahmer reports grants from Bundesministerium für Bildung und Forschung (BMBF) (an unrestricted research grant for the German Center for Lung Research (DZL)), during the conduct of the study, and personal fees from AstraZeneca, GlaxoSmithKline, Novartis and Roche, outside the submitted work. The remaining authors report no relevant conflicts of interest."

"Support statement: The ALLIANCE infrastructure is provided by the participating sites of the German Center for Lung Research (DZL) and associated study centres and hospitals. Direct costs of the ALLIANCE cohort are paid by project grants from the German Federal Ministry of Education and Research (Bundesministerium für Bildung und Forschung (BMBF)), grant number 82DZL001A4. Funding information for this article has been deposited with the Crossref Funder Registry."

"Eligible subjects were adult asthma patients who participated in the multicentre All Age Asthma Cohort (ALLIANCE), a longitudinal observational cohort study of paediatric and adult asthma patients, initiated by the German Center for Lung Research (DZL). The study was approved by the ethics committee at the University of Lübeck School of Medicine (Lübeck, Germany; Az.21-215) and is registered at ClinicalTrials.gov (adult arm: NCT02419274). Written informed consent was obtained before enrolment. This longitudinal analysis included adult patients with mild-to-severe asthma who underwent a pulmonary function test, using IOS, at baseline and after 1-year follow-up. The participants had to have stable disease at the time of assessment, i.e. absence of acute exacerbations or respiratory tract infections within 4 weeks prior to study visit. Detailed information on recruitment, inclusion and exclusion criteria of the ALLIANCE cohort are as previously described []."