Disruption of protein geranylgeranylation in the cerebellum causes cerebellar hypoplasia and ataxia via blocking granule cell progenitor proliferation.

"raw data were shown in additional file 2"

"Declarations Ethics approval and consent to participateAll the mouse experiments were performed in accordance with the Guide for the Animal Care and Use Committee of the Model Animal Research Center of Nanjing University. Consent for publicationAll authors have agreed to publish this manuscript. Competing interestsThe authors declare no competing financial interests. Competing interests The authors declare no competing financial interests."

"Funding This work was supported by the Chinese National Science Foundation (32271187, 32071142), Qin Lan Project of Jiangsu Province (KY520R202025), Collaborative Innovation Center for Cancer Personalized Medicine-Clinical Research Fund of Hengrui Medicine (JZ21449020210617)."