Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration and mechanism of action analyses.

"DECLARATION OF INTERESTS: The authors declare that they have no conflicts of interest."

"This work was supported by the National Institute on Drug Abuse (UG1DA013732, CTN-0114) and the Clinical and Translational Science Collaborative (CTSC) of Cleveland (UL1TR002548–01). U.E.G. was substantially involved in CTN-0114, consistent with his role as Scientific Officer. He had no substantial involvement in the other cited grants. The views and opinions expressed in this manuscript are those of the authors only and do not necessarily represent the views, official policy or position of the US Department of Health and Human Services or any of its affiliated institutions or agencies. We would like to acknowledge the efforts of members of the CTN-0114 Advisory Committee: Kathleen Brady MD, PhD; Todd Korthuis MD, MPH; Sean Luo PhD; Edward Nunes MD; John Rotrosen MD; Andrew Saxon MD; and Steven Shoptaw PhD."