Lung volume reduction surgery <i>versus</i> endobronchial valves: a randomised controlled trial.

"Conflict of interest: D. Waller reports lecture honoraria from PulmonX Ltd, outside the submitted work. N.J. Greening reports grants from GSK, consulting fees from Genentech, lecture honoraria from AstraZeneca and Chiesi, travel support from Chiesi, outside the submitted work. P.L. Shah reports lecture honoraria from PulmonX Ltd, outside the submitted work. R. Bilancia reports lecture honoraria and travel support from Intuitive, outside the submitted work. R. Lawson is a Member of British Thoracic Society COPD Specialist Advisory group, a Member of South Yorkshire Clinical Senate, and a Member of South Yorkshire and Bassetlaw Respiratory Clinical Network, outside the submitted work. All other authors have nothing to disclose."

"Support statement: This project was funded by the National Institute for Health Research (NIHR) under its Research for Patient Benefit Programme (grant reference number PB-PG-1014-35051). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. Imperial College London will support the reporting of this manuscript. Trial sponsor representative: Patrik Pettersson, Royal Brompton and Harefield NHS Foundation Trust, Royal Brompton Hospital. The funder of the study had no role in study design, data collection, data analysis, data interpretation or writing of the report. Funding information for this article has been deposited with the Crossref Funder Registry."

"Ethical approval was obtained from Fulham Research Ethics Committee (London, UK) (REC reference: 16/LO/0286). The trial protocol has been published previously []. The trial was registered prospectively at the ISRCTN registry with identifier ISRCTN19684749. A trial steering committee with an independent chair met quarterly to review progress, conduct, safety and consistency of trial processes and decision making at each centre throughout the course of the trial. This study was prospectively registered at the ISRCTN registry with identifier ISRCTN19684749. Fully anonymised data will be provided upon reasonable request to the corresponding author."