Neurological soft signs are increased in major depressive disorder irrespective of treatment.

"Declarations Conflict of interestHBM and RS took part in an educational event sponsored by Livanova, a manufacturer of vagus nerve stimulation devices. MD receives consulting fees from Saniona. AN received lecture fees from Novartis and Merck. HF received speaker ‘s honararia and served as advisor for Recordati Pharma GmbH and Janssen-Cilag Gmbh. The other authors declare that they have no conflicts of interest. Conflict of interest HBM and RS took part in an educational event sponsored by Livanova, a manufacturer of vagus nerve stimulation devices. MD receives consulting fees from Saniona. AN received lecture fees from Novartis and Merck. HF received speaker ‘s honararia and served as advisor for Recordati Pharma GmbH and Janssen-Cilag Gmbh. The other authors declare that they have no conflicts of interest."

"Funding Open Access funding enabled and organized by Projekt DEAL."