The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway.

"Declaration of competing interest The authors declare that there are no conflicts of interest."

"We are grateful to the Beijing Key Laboratory of Traditional Chinese Medicine Quality Evaluation for providing experimental instruments and equipment. We thank Beijing University of Chinese Medicine for providing the laboratory platform. The authors would like to express their gratitude to Edit Springs (https://www.editsprings.cn/) for the expert linguistic services provided. This work was supported by the 10.13039/501100001809National Natural Science Foundation of China (Grant No.: 82204753), the Scientific Research Staring Foundation for the New Teachers of Beijing University of Chinese Medicine (Grant No.: 2020-JYB-XJSJJ-009), and Special Scientific Research for Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine of China (Grant No.: 201507004). The funders had no role in the study design, data collection, data analysis, interpretation, or writing of the report."