Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia.

"data availability rna next-generation atac and cut&run sequencing data have been submitted to the gene expression omnibus (accession number gse217113).; additional rna-seq samples were previously deposited in the gene expression omnibus (accession number gse54478). data availability rna next-generation atac and cut&run sequencing data have been submitted to the gene expression omnibus (accession number gse217113"

"Competing interests The authors declare no competing interests."

"The authors would like to thank Constanze Bonifer for carefully reading the manuscript, Cor Seinen (UMC Utrecht) for performing the cryoEM, Shalini Sankar for testing siRE in MV4-11 cells, and the staff of the Comparative Biology Centre (CBC) at Newcastle University for supporting the in vivo experiments. OH is supported by grants from Cancer Research UK (C27943/A23389), Bloodwise (15005), Kay Kendall Leukemia Fund (KKL1142), the North of England Children’s Cancer Fund and KIKA (329). HI was supported by an AKEB Aga Khan fellowship."