Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice.

"barplot dotplot and pca plots were constructed using ggplot2 in r heatmaps were generated using the "pheatmap" function in r all analyses and visualizations were performed in r computer code is available upon request scrna-seq data have been deposited in the ncbi gene expression omnibus as gse202110 . data s1 includes the full list of degs output by seurat for the clusters described in fig 7 and fig s3 .; data s2 contains the inferred germline mrl/lpr v region sequences used for bcr mutation analysis in fig 8 .; data s1 includes the full list of degs output by seurat for the clusters described in fig 7 and fig s3.; data s2 contains the inferred germline mrl/lpr v region sequences used for bcr mutation analysis in fig 8."

"Disclosures: K.B. Hoehn reported personal fees from Prellis Biologics outside the submitted work. S.H. Kleinstein reported consulting fees from Peraton. No other disclosures were reported."

"This work was supported in part by National Institutes of Health (NIH) R21AI141938 and a Novel Research Grant from the Lupus Research Alliance (to K.M. Nickerson), NIH R37AI118841 (to M.J. Shlomchik), and NIH R01AI104739 (to S.H. Kleinstein)."