Pleiotrophin drives a prometastatic immune niche in breast cancer.

"data availability all raw data generated in this manuscript have been deposited in gene expression omnibus under accession no gse200431 . data availability all raw data generated in this manuscript have been deposited in gene expression omnibus under accession no gse200431"

"Disclosures: Y.V. Fang reported personal fees from Integro Theranostics outside the submitted work. A. Wellstein reported a patent to US7888485B2 issued. No other disclosures were reported."

"We thank Dr. John Chute (Cedars Sinai Medical Center, Los Angeles, CA, USA) for providing Ptn-null mice. We acknowledge helpful input from other members of the Brekken laboratory, especially Dr. Huocong Huang. We also thank Drs. Srinivas Malladi and Maralice Conacci-Sorrell for critical evaluation of the manuscript. Lastly, we thank the following UT Southwestern core facilities: McDermott Center Next-Generation Sequencing Core, Moody Foundation Flow Cytometry Core, Flow cytometry facility, Whole brain microscopy facility, Live Cell Imaging core, and Histopathology core and Tissue Management Shared Resources (P30 CA142543). All schematic cartoons were created with BioRender.com. This work was supported by grants from the Mary Kay Foundation, METAvivor, the National Institutes of Health (CA243577), and the Effie Marie Cain Fellowship in Angiogenesis Research to R.A. Brekken."