Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain.

"log2 transformed expression values of jchain (probe: 212592_at) and sdc1 (probe: 201286_at) were retrieved from publicly available microarray dataset (gse: 13591; https://www ncbi nlm nih gov/geo/geo2r/?"

"Declarations Ethics approval and consent to participatePatient and healthy donor materials were collected after written informed consent according to the Declaration of Helsinki. MM patient material from the Leiden University Medical Center Biobank for Hematologic Diseases was used in this study. The study was approved by the Institutional Review Board of the Leiden University Medical Center (approval number 3.4205/010/FB/jr) and the METC-LDD (approval number HEM 008/SH/sh). Competing interestsJHFF and MHMH are inventors on a filed patent application (patent number P319797NL) ‘T cell receptors against Jchain and uses thereof.’ The other authors declare no competing interests. Competing interests JHFF and MHMH are inventors on a filed patent application (patent number P319797NL) ‘T cell receptors against Jchain and uses thereof.’ The other authors declare no competing interests."

"Funding This project was funded by the Dutch Cancer Society (KWF kankerbestrijding, Amsterdam, the Netherlands) under grant number KWF UL-2014-6831."