Chronic exposure to a synthetic cannabinoid alters cerebral brain metabolism and causes long-lasting behavioral deficits in adult mice.

"Declarations Conflict of interestThe author(s) declare that they have no conflict of interest. Ethical approvalAll animals were handled according to the German guidelines and EU legislation for animal care and the experiments were approved by the local authorities (Niedersächsisches Landesamt für Verbraucherschutz [16/2364, 17/2614] and Landesamt für Gesundheit und Soziales LAGeSo Darwinstr. 15, 10589 Berlin [65/18, 260/19]). Conflict of interest The author(s) declare that they have no conflict of interest."

"Funding Open Access funding enabled and organized by Projekt DEAL. This study was supported by the “Alzheimer Stiftung Göttingen” to CB and YB. This work was supported in part by the Deutsche Forschungsgemeinschaft (DFG) for PET/MRI use (INST 335/454-1FUGG)."