Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies.

"the principles of each aspect of our harmonisation procedure are described in the following sections and presented in a flow chart available in our osf repository .; the last columns of the table on 'details of included articles and original and harmonized exposures' in the same osf repository contain the details of how the original pa exposure categories of each study were harmonised to mmet-hours/week values.; details of all selected and excluded articles can be found in our osf repository and data underlying each of the dose-response estimations can be downloaded at https://shiny mrc-epid cam ac uk/meta-analyses-physical-activity / ."

"syntax for all analyses and the interactive interface are available at https://github com/meta-analyses/ ."

"Competing interests: None declared."

"Funding: LG, AA and JW were supported by METAHIT, an MRC Methodology Panel project (MR/P02663X/1). AA, MP and JW have received funding from the European Research Council (ERC) under the Horizon 2020 Research and Innovation Programme (grant agreement 817754) (this material reflects only the authors’ views and the Commission is not liable for any use that may be made of the information contained therein). LG, AA and JW were supported by the Centre for Diet and Activity Research (CEDAR), a UKCRC Public Health Research Centre of Excellence funded by the British Heart Foundation, Cancer Research UK, Economic and Social Research Council, Medical Research Council, the National Institute for Health Research (NIHR) and the Wellcome Trust (MR/K023187/1). PCD was supported by a National Health and Medical Research Council of Australia Research Fellowship (no: 1142685). RG was supported by a Gates Cambridge Scholarship. MP and SB were supported by the NIHR Biomedical Research Centre, Cambridge (IS-BRC-1215-20014). AM was supported by the National Science Scholarship from Singapore, A*STAR. THdS was supported by the São Paulo Research Foundation (2012/08565-4 and 2013/25624-7) and the National Council for Scientific and Technological Development (200358/2014-6 and 402648/2015-3). MP, TS, PCD, KW and SB were supported by UK Medical Research Council (MC_UU_12015/3, MC_UU_00006/4)."

"The study protocol is available at PROSPERO (registration number CRD42018095481). Conclusions: Inverse non-linear dose–response associations suggest substantial protection against a range of chronic disease outcomes from small increases in non-occupational physical activity in inactive adults.: PROSPERO registration number CRD42018095481."