Critical Closing Pressure and Cerebrovascular Resistance Responses to Intracranial Pressure Variations in Neurocritical Patients.

"Conflicts of interest The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article."

"Source of Support The present study received no funding."

"This is a single center, prospective, observational study performed at Hospital das Clínicas, São Paulo University, Brazil. The study protocol was approved by the local Ethics Committee, in May/23/2017 (REB register 66721217.0.0000.0068) and registered under number NCT03144219 (available at ClinicalTrials.gov). All methods were performed in accordance with the relevant guidelines and regulations, and informed consent was obtained from all legally authorized representatives or next of kin instead of the patients because of illness severity. Clinical Trial Registration: Trial registration: NCT03144219, Registered 01 May 2017 Retrospectively registered, https://www.clinicaltrials.gov/ct2/show/NCT03144219: ClinicalTrials.gov: NCT03694678."