Safety and efficacy of oxybutynin in patients with hyperhidrosis: systematic review and meta-analysis of randomized controlled trials.

"Declarations Competing interestsThe authors declare no competing interests. Conflict of interestAll authors have no conflict of interest. Ethical approvalThis article does not contain any studies with human participants or animals performed by any of the authors. Protocol registrationThe protocol of this study was registered on PROSPERO (CRD 42022342667). Competing interests The authors declare no competing interests. Conflict of interest All authors have no conflict of interest."

"Funding Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). No funding was received for this research."

"All steps have been done according to the Cochrane Handbook of Systematic Reviews and Meta-analysis of Interventions []. All steps of this study were prespecified, and the protocol was registered on PROSPERO (CRD42022342667). Methods: We prospectively registered the protocol of this systematic review and meta-analysis on PROSPERO (CRD 42022342667). This systematic review and meta-analysis were reported according to the PRISMA statement guidelines. We searched three electronic databases (PubMed, Scopus, Web of Science) from inception until June 2, 2022, using MeSH terms. We include studies comparing patients with hyperhidrosis who received oxybutynin or a placebo. We assessed the risk of bias using the Cochrane risk of bias assessment tool (ROB2) for randomized controlled trials. The risk ratio was calculated for categorical variables, and the mean difference was calculated for continuous variables using the random effect model with 95% confidence intervals (CI). Declarations: Competing interestsThe authors declare no competing interests.: Conflict of interestAll authors have no conflict of interest.: Ethical approvalThis article does not contain any studies with human participants or animals performed by any of the authors.: Protocol registrationThe protocol of this study was registered on PROSPERO (CRD 42022342667). Protocol registration: The protocol of this study was registered on PROSPERO (CRD 42022342667)."