First-Line Systemic Therapies for Advanced Hepatocellular Carcinoma: A Systematic Review and Patient-Level Network Meta-Analysis.

Authors:
Fong KY; Zhao JJ; Sultana R; Lee JJX; Lee SY and 5 more

Journal:
Liver Cancer

Publication Year: 2022

DOI:
10.1159/000526639

PMCID:
PMC9982345

PMID:
36872922

Journal Information

Full Title: Liver Cancer

Abbreviation: Liver Cancer

Country: Unknown

Publisher: Unknown

Language: N/A

Publication Details

Subject Category: Gastroenterology & Hepatology

Available in Europe PMC: Yes

Available in PMC: Yes

PDF Available: No

Transparency Score
3/6
50.0% Transparent
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Evidence found in paper:

"Conflict of Interest Statement Joycelyn Jie Xin Lee has received research funding from Bayer; honoraria for presentations from Ipsen and BMS; and advisory boards with Bayer, Ipsen, Taiho, and Eisai. Stephen Lam Chan has received honoraria from Bayer; has consulting or advisory roles in AstraZeneca/MedImmune, MSD Oncology, and Novartis; speakers' bureau from Amgen, Bayer, and Eisai; and research funding from Novartis and Sirtex Medical. Thomas Yau reports consulting fees from, honoraria from, and participation on a data safety monitoring board or advisory board for AbbVie, AstraZeneca, Bayer, Bristol Myers Squibb, Eisai, Eli Lilly, EMD Serono, Exelixis, H3 Biomedicine, Ipsen, Merck Sharp and Dohme, New B Innovation, Novartis, OrigiMed, Pfizer, Sillajen, Sirtex, and Taiho Pharmaceutical. David Wai Meng Tai has received research funding from Bristol-Myers Squibb, Sirtex, and NMRC Singapore; payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events from Ipsen, Eisai, and Bristol-Myers Squibb; and consulting fees from Novartis, Bristol-Myers Squibb, and Merck Sharpe Dohme. Raghav Sundar has received honoraria from Bristol-Myers Squibb, Lilly, Roche, Taiho, Astra Zeneca, DKSH, and MSD; has advisory activity with Bristol-Myers Squibb, Merck, Eisai, Bayer, Taiho, Novartis, MSD, and AstraZeneca; received research funding from MSD and Paxman Coolers; and has received travel grants from AstraZeneca, Eisai, Roche, and Taiho Pharmaceutical. Chow Wei Too has received payment or honoraria for lectures, presentations, speakers bureaus, manuscript writing, or educational events and consulting fees from Sirtex."

Evidence found in paper:

"David Wai Meng Tai is supported by the National Medical Research Council Singapore (NMRC; NMRC/CIRG/1470/2017 and NMRC/CIRG/1454/2016). Raghav Sundar is supported by the National Medical Research Council Singapore (NMRC; NMRC/Fellowship/0059/2018 and NMRC/MOH/000627). The above funding organizations had no role in this study."

Protocol Registration
Open Access
Paper is freely available to read
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Last Updated: Aug 05, 2025