B cell receptor ligation induces IgE plasma cell elimination.

"Disclosures: Z. Yang reported “other” from Genentech outside the submitted work and is a shareholder in the Roche Group. C.D.C. Allen reported personal fees from Walking Fish Therapeutics outside the submitted work; and “my spouse is an employee and shareholder of Bristol Myers Squibb.” No other disclosures were reported."

"We thank J.B. Jung for assistance with bone marrow chimera experiments; J. Taunton and G.A. Smith (both UCSF, San Francisco, CA, USA) for generously providing ibrutinib for our studies; S. Elmes from the Laboratory for Cellular Analysis Core (supported by National Institutes of Health Grant P30CA082103) for technical assistance with cell sorting experiments; the Gladstone Flow Cytometry Core (supported by National Institutes of Health Grant P30 AI027763) for their technical support with Ca2+ flux experiments; and J.G. Cyster, K.M. Ansel, J. Zikherman, and J.F.E. Koenig for advice and comments on the manuscript. This research was supported by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health under Award Number R01AI130470; the Program for Breakthrough Biomedical Research, which is partially funded by the Sandler Foundation; the Sandler Asthma Basic Research Center; and the Cardiovascular Research Institute at UCSF. C.D.C. Allen was a Pew Scholar in the Biomedical Sciences, supported by The Pew Charitable Trusts. A.K. Wade-Vallance was supported by a Doctoral Foreign Study Award from the Canadian Institute of Health Research, funding reference number DFD-170769. D.M. Tarlinton and M.J. Robinson were funded by National Health and Medical Research Council Australia by an Investigator Award (APP1175411) and Ideas Grant (APP1185294), respectively. The content is solely the responsibility of the authors and does not necessarily represent the official views of the funding agencies."