Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy.

"Declarations Ethics approval and consent to participateNot applicable. Consent for publicationNot applicable. Competing interestsM.X. is an employee of Genentech. D.M.H. is as an inventor on a patent licensed by Washington University to NextCure on the therapeutic use of anti-APOE antibodies. D.M.H. co-founded and is on the scientific advisory board of C2N Diagnostics. D.M.H. is on the scientific advisory board of Denali, Genentech, and Cajal Neuroscience and consults for Alector. All other authors declare that they have no competing interests to disclose. Competing interests M.X. is an employee of Genentech. D.M.H. is as an inventor on a patent licensed by Washington University to NextCure on the therapeutic use of anti-APOE antibodies. D.M.H. co-founded and is on the scientific advisory board of C2N Diagnostics. D.M.H. is on the scientific advisory board of Denali, Genentech, and Cajal Neuroscience and consults for Alector. All other authors declare that they have no competing interests to disclose."

"Funding This work was supported by NIH grants AG062027 (M.X.), RF1NS090934 (D.M.H.), RF1AG047644 (D.M.H.), R01 NS034467 (D.M.H.), P01 AG078106 (D.M.H.), the BrightFocus foundation A2018128F (C.W.) and A2020257F (M.G.), Cure Alzheimer’s Fund (D.M.H.), and the JPB Foundation (D.M.H.). Images scanned on the Hamamatsu NanoZoomer digital pathology system is courtesy of the Hope Center Alafi Neuroimaging Laboratory."