Enrichment of transgene integrations by transient CRISPR activation of a silent reporter gene.

"Declaration of interests R.O.B. holds equity in Graphite Bio and UNIKUM Tx and is a part-time employee of UNIKUM Therapeutics. J.L.S. is an employee of Novo Nordisk. T.I.J. is an employee of UNIKUM Therapeutics."

"Funding in the Bak Lab is supported by a grant from the Danish Health Authorities (SST) (4-1612-391/1), the EU Commission in the form of an ERC starting grant (project 101041231, Horizon Europe Pillar I) and a grant from the Horizon Research and Innovation Actions (project 101057438, Horizon Europe Pillar II), a 10.13039/501100003554Lundbeck Foundation fellowship (R238-2016-3349), the Independent Research Fund Denmark (0134-00113B, 0242-00009B, and 9144-00001B), an AIAS-COFUND (Marie Curie) fellowship from the 10.13039/501100009388Aarhus Institute of Advanced Studies (AIAS) co-funded by Aarhus University’s Research Foundation and the European Union’s Seventh Framework Program under grant agreement 609033, the 10.13039/501100009708Novo Nordisk Foundation (NNF19OC0058238 and NNF17OC0028894), 10.13039/100012774Innovation Fund Denmark (8056-00010B), the 10.13039/501100002808Carlsberg Foundation (CF20-0424 and CF17-0129), Slagtermester Max Wørzner og Hustru Inger Wørzners Mindelegat, the 10.13039/501100005747A.P. Møller Foundation, the 10.13039/501100006309Riisfort Foundation, the Agnes and Poul Friis’ Foundation, and a Genome Engineer Innovation grant from Synthego. We would like to thank the FACS Core Facility at Aarhus University for providing invaluable help with flow cytometry and Niels Uldbjerg, Lars Henning Pedersen, and Hai Qing Tang from Aarhus University Hospital for obtaining consent and procuring cord blood. A special thanks to Pernille Thornild Møller for technical assistance."