A Review of the Cardiovascular Safety of Prucalopride in Patients With Chronic Idiopathic Constipation.

"CONFLICTS OF INTEREST Guarantor of the article: Jan Tack, MD, PhD. Specific author contributions: All authors were involved in the planning and conduct of this review; all authors were involved in the collection and interpretation of data and drafting of the manuscript. All authors approved the final draft submitted. Financial support: This review was funded by Takeda Pharmaceuticals USA. Medical writing support was provided by Sharon Smalley for PharmaGenesis London, London, UK, and funded by Takeda Pharmaceuticals USA. Potential competing interests: J.T.: has given scientific advice to Adare Pharmaceuticals, Alfa Wassermann, Allergan, Arena Pharmaceuticals, Bayer, Christian Hansen, Clasado Biosciences, Danone, Devintec, Dr Falk, Grünenthal, Ironwood Pharmaceuticals, Janssen Pharmaceuticals, Kyowa Kirin, Menarini, Mylan, Neurogastrx, NeuTec, Novartis, Noventure, Nutricia, Shionogi, Shire, a Takeda company, Takeda, Theravance BioPharma, Tramedico, Truvion Healthcare, Tsumura, Zealand Pharma, and Zeria Pharmaceutical. He has received research support from Shire, a Takeda company, Sofar, Takeda, and Tsumara and has served on speaker bureaus for Abbott, Allergan, AstraZeneca, Janssen Pharmaceuticals, Kyowa Kirin, Menarini, Mylan, Novartis, Shire, a Takeda company, Takeda, Truvion Healthcare, and Zeria Pharmaceutical. K.D.: is an employee of Takeda Development Center Americas and is a stockholder of Takeda Pharmaceutical. A.G.: is an employee of Takeda Development Center Americas and is a stockholder of Takeda Pharmaceutical. W.S.: is an employee of Takeda Development Center Americas and is a stockholder of Takeda Pharmaceutical. B.T.: is an employee of Takeda Pharmaceuticals USA and is a stockholder of Takeda Pharmaceutical. A.Y.: is an employee of Takeda Pharmaceuticals USA and is a stockholder of Takeda Pharmaceutical. B.K.: has no relationships relevant to the contents of this study to disclose. P.R.K.: is a consultant for Takeda. M.B.: is an employee of Takeda Pharmaceuticals USA and is a stockholder of Takeda Pharmaceutical."

"Financial support: This review was funded by Takeda Pharmaceuticals USA. Medical writing support was provided by Sharon Smalley for PharmaGenesis London, London, UK, and funded by Takeda Pharmaceuticals USA."