Inhibition of ERK1/2 signaling prevents bone marrow fibrosis by reducing osteopontin plasma levels in a myelofibrosis mouse model.

"Competing interests The authors declare no competing interests."

"This work was supported by the following grants from AIRC (Associazione Italiana per la Ricerca sul Cancro, Milan, Italy): 5 × 1000 call “Metastatic disease: the key unmet need in oncology” to MYNERVA (MYeloid NEoplasms Research Venture AIRC), Project No. 21267 (a detailed description of the MYNERVA project is available at http://www.progettomynerva.it) and IG project #19818; the Italian Ministry of Health (project RF-2016- 02362930), and the Ministry of Education, University and Research (project #2017WXR7ZT_005). Sebastiano Rontauroli was supported by a AIRC fellowship for Italy (project number #23925 – 2019). We thank Antonella Mauro for providing technical support for in vivo experiments."