Indirect epigenetic testing identifies a diagnostic signature of cardiomyocyte DNA methylation in heart failure.

"all coding scripts used in the current study are available as an online supplement via github data repository: https://github com/mepepin/indirect epigenomics . supplemental table 2: fragment analysis of rna. supplementary file6 (csv"

"all coding scripts used in the current study are available as an online supplement via github data repository: https://github com/mepepin/indirect epigenomics . all coding scripts used in the current study are available as an online supplement via github data repository: https://github com/mepepin/indirect epigenomics ."

"Declarations Conflict of interestJB holds a patent on "In vitro method for cardiovascular risk stratification, EP2954322B1". Conflict of interest JB holds a patent on "In vitro method for cardiovascular risk stratification, EP2954322B1"."

"Funding Open Access funding enabled and organized by Projekt DEAL. J.B. was supported by grants from the MWK (‘Development of an indirect cardiomyocyte test for the prediction of heart failure’; AZ 32–5400/58/2), and the DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung—German Centre for Cardiovascular Research) and the BMBF (German Ministry of Education and Research). M.E.P. was supported by the Alexander von Humboldt Forschungsstipendium, the Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), and the Deutsche Gesellschaft für Kardiologie. C.U.O. was supported by DFG (OE 688/1–1), BIH Charité Clinician Scientist Program, and Orlovic-Nachwuchsfonds Innovative Cardiology. B.M. was supported by the DZHK (Deutsches Zentrum für Herz-Kreislauf-Forschung—German Centre for Cardiovascular Research) and by the BMBF (German Ministry of Education and Research). J.B., T.W. and B.M. were supported by the Collaborative Research Center 1550 (CRC1550 /SFB1550) ‘Molecular Circuits of Heart Disease’ – Project-ID 464424253."