Overexpression of hypoxia-inducible factor-1α in hidradenitis suppurativa: the link between deviated immunity and metabolism.

"none data availability all data analyzed in this study are included in the published article as dataset s1 and dataset s2."

"Declarations Competing interestsThe authors declare no competing interests. Conflict of interestThe authors have declared no conflicting interests. Competing interests The authors declare no competing interests. Conflict of interest The authors have declared no conflicting interests."

"Funding Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). None"

"This study included 20 patients suffering from hidradenitis suppurativa and 20 socio-demographically cross-matched healthy controls. All participants were recruited from the Dermatology Outpatient Clinic of the Alexandria Main University Hospital. Approval by ethical committee as well as written informed consent was obtained from all patients and controls. All procedures were in accordance with the ethical standards of the institutional and/or national research committee and the 1964 Declaration of Helsinki and registered with IRB No.: 00012098, FWA No.: 00018699. Patients with other concomitant lesions in the diseased area, patients who were receiving therapy for HS during the last 6 months, pregnant and lactating females were excluded. Patients were subjected to a full history, general medical and dermatological examination. Severity of HS was graded by the Hurley system: stage I: solitary or multiple, isolated abscess formation without scarring or sinus tracts; stage II: recurrent abscesses, single or multiple widely separated lesions, with sinus tract formation; stage III: diffuse or broad involvement, with multiple interconnected sinus tracts and abscesses []."