Exogenous aralar/slc25a12 can replace citrin/slc25a13 as malate aspartate shuttle component in liver.

"Conflict of interest statement Authors declare no competing interests."

"This work was supported by the CITRIN FOUNDATION, in Singapore founded by Barbara Yu Fa and Yen How Tai (to J.S.), by 10.13039/501100004837MICINN [grant PID2020-114499RB-I00 AEI/FEDER, UE, to A. del A.], by Instituto de Investigación Hospital 12 de Octubre (Imas12), Madrid, Spain [grant 2019/0039 to M.P.-C.] by Ministerio de Ciencia, Innovación y Universidades MICINN [grant PID2020-117116RB-I00 in “Plan Estatal de Investigación Cientifica y Técnica y Innovación, cofinanciado con Fondos FEDER (to M.L.M.-C.]; by La Caixa Foundation Program (to M.L.M.-C.), by Programa Retos [RTC2019-007125-1, to M.L.M.-C.)], Proyectos Investigacion en Salud [DTS20/00138 to M.L.M.-C.], and by institutional grant from Fundación Areces to the Centro de Biología Molecular Severo Ochoa. L.G.-M. was recipient of predoctoral fellowship from MINECO and A.S.-C. was recipient of a predoctoral research contract from Comunidad de Madrid. We thank Bárbara Sesé, Beatriz García, and Pilar del Hoyo for excellent technical assistance, Belén Pintado and Verónica Domínguez for discussion and assistance on transgenic mice generation; and Optical and Confocal Microscopy unit (SMOC) of the CBMSO for their support."