LCN2 secreted by tissue-infiltrating neutrophils induces the ferroptosis and wasting of adipose and muscle tissues in lung cancer cachexia.

"the rna-seq data generated in this study were deposited in the geo database repository and can be accessed using with the accession number gse188479.; availability of data and materials microarray data were deposited into the national center for biotechnology information geo repository (accession number: gse188479). availability of data and materials microarray data were deposited into the national center for biotechnology information geo repository (accession number: gse188479"

"Declarations Ethical approval and consent for participateAll procedures involving experimental animals were approved by the Ethics Committee of the University of Science and Technology of China (USTCACUC1701038) and were performed in accordance with the National Guidelines for Animal Usage in Research. All human samples were collected with the informed consent of the patients, and the experiments were approved by the Ethics Committee of the University of Science and Technology of China (2020-research-36). Details relating to the patients’ cancer type and cachexia are listed in Additional file 4: Table S5. Competing interestsThe authors declare that they have no competing interests. Competing interests The authors declare that they have no competing interests."

"Funding This work was supported by the Natural Science Foundation of China (Reference number: U19A2024, 82122055, 82241216, 32270963), the CAMS Innovation Fund for Medical Sciences (CIFMS, 2019-I2M-5-073), and the Strategic Priority Research Program of the Chinese Academy of Sciences (XDPB1002, XDB39020700)."