Process intensification for lentiviral vector manufacturing using tangential flow depth filtration.

"Declaration of interests The work was funded by GSK, and all authors were employed by GSK at the time of executing experimental procedures. Several authors are GSK shareholders."

"We would like to acknowledge Nathaniel Berendson, Chandrima Sinha, Nithya Krishnan, Alex McGregor, and Kyle Kleinberg for permitting us to utilize historical data for comparison with TFDF perfusion data and Victoria Ng for assisting with sample testing. We would also like to thank Repligen for providing a demo KrosFlo unit to evaluate the membranes and system for the non-perfusion experiments described in Figure 1. This work was funded by 10.13039/100004330GSK. Declaration of interestsThe work was funded by GSK, and all authors were employed by GSK at the time of executing experimental procedures. Several authors are GSK shareholders."