Minimal and normal-flow general anesthesia in patients undergoing surgery in prone position: ımpact on hemodynamics and regional cerebral oxygenation.

"Conflict of Interest: Nothing to declare."

"Funding: Not applicable."

"This was a randomized prospective comparative study that aimed to evaluate the likely changes in cerebral oxygenation and hemodynamic parameters with the use of minimal fresh gas flow systemic anesthesia in patients undergoing surgery in a PP. The study protocol was approved by the local ethics committee decision no: 1477 (05/11/2019) and the Clinical Trials registration was submitted retrospectively on 18/07/2022 and its ID number was NCT05462327. All patients were informed about the study protocol and signed written informed consent forms before enrolling in the study. All study procedures were performed in full compliance with the principles of the Declaration of Helsinki."