Tespa1 facilitates hematopoietic and leukemic stem cell maintenance by restricting c-Myc degradation.

"data availability the raw data of rna-seq were deposited in ncbi geo database with accession number gse211292 and gse211117. data availability the raw data of rna-seq were deposited in ncbi geo database with accession number gse211292"

"Competing interests The authors declare no competing interest."

"We thank Prof. Jinyong Wang for gifting CD45.1 mice, Prof. Yajing Chu for gifting MSCV-MLL-AF9-IRES-GFP plasmid, Jing Zhao for technical support in flow cytometry and Liting Wang for technical support in immunofluorescence microscopy. This work was supported by grants from the National Natural Science Foundation of China (No. 81930090, 82203974, 81725019), Post-doctoral Innovative Talent Support Program of China (No. BX20220398) and Post-doctoral Innovative Talent Support Program of Chongqing (No. CQBX2021017)."