Autoimmunity and immunodeficiency associated with monoallelic LIG4 mutations via haploinsufficiency.

"Disclosure of potential conflict of interest: The authors declare that they have no relevant conflicts of interest."

"M.R. was supported by the Swiss National Science Foundation (grants PP00P3_181038 and 310030_192652). A.J. was supported by the Swiss Cancer League (grant SNF 323630_151483) and Novartis Foundation for Medical-Biological Research. This work was supported by grants from the Swiss National Supercomputing Center (CSCS) to O.B. under the project IDs sm09 and s1099. J.T. was supported by the Swiss National Science Foundation (grants PZ00P3_161147 and PZ00P3_1837777). S.E. was supported by the BMBF GAIN consortium (grants TP6; 01GM1910A). This work was partially supported by the Japan Agency for Medical Research and Development (AMED) (grants JP19fm0208017 and JP22wm0325006) and the Takeda Science Foundation to H.Y.H.Y.was supported by the Swiss National Science Foundation (grant 310030_192652). S.S. was supported by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan (JSPS) Grant-in-Aid for Early-Career Scientists [22K15480]. L.D.N. is supported by the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health."